Occupational Health - Public
Health Poster Session
Re: Poster 811 Guest
On Sun Dec 6, Grover wrote
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>Dr. Ritchie: Hope you are enjoying the meeting. Great poster.Do you think that rat is the best animal model for studies on teratogenesis using embryos? Would some of the phylogenetically more related models not be better?
>It really depends on what endpoint you are after. With embryo culture we are limited to the studying the early stages of craniofacial devlopment. Even so, this is only possible because rodents have a yolk sac placenta which enables this lat culture. If you wanted to look at neonates then they may look more human (eg. some use Macaque monkeys) but you probably can't culture them and you would still have pharmacokinetic differences to deal with if you only use in vivo methodologies.
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Tue Dec 8