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Dave Kennaway
dkennawa@medicine.adelaide.edu.au
This is an interesting study. I have been fascinated by your original observations for some time and I am glad that you are back studying the phenomenon again. Do you intend attempting suprachiasmatic nucleus destruction in rats infused with PHNO? I suspect that the tolerance sensitisation is occurring at a site innervated by efferents from the SCN. The tracing literature should give you some clues where to look further.
Dave Kennaway
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Tue Dec 8