>There are examples in clinical medicine other than intrinsic asthma which may point to a separate and distinct contributory role for CD4 (and possibly CD8) cells in eosinophilic inflammation: namely, nasal polyposis (associated with intrinsic asthma) and occupational asthma.
>The million dollar question is obviously: which cytokine(s) mediate the CD4 effect in your mouse model?
Do you mean in the development of the CD4 cell or its recruitment to the lung? Perhaps interleukin-13 can replace some of the IL-4 mediated functions and there is evidence in some mouse systems that IL-16 is important in recruitment.
Paul Foster, Ian Young, Klaus Matthaei