SERCA-Type of Calcium Pumps and Phospholamban

Thanx

Dr. Leonard:
Another way to look at it may be that SERCA3 control occurs mainly in an area where it is not advantageious to reach a very low Ca concentration.
akg

On Mon Dec 14, Leonard DODE wrote
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>On Sat Dec 12, grover wrote
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>>Len:
>> Thanx for the response. I have considered the PMCA pumps more for cell survival and SERCA pumps more for signal transduction (Grover 1985, Cell Calcium). What do you think of that idea?
>>akg

>>Dear dr. Grover,
>Indeed, the general idea is that SERCA pumps are required for the termination of the transient calcium signal after cell stimulation together with the concerted action of PMCA pumps and/or sodium-calcium exchanger. But, let's not forget that SERCA1, SERCA2, and PMCA display high affinities for calcium and in normal condition this might be sufficient for a cell to survive the transitory increases in cytosolic calcium concentration. What about SERCA3 with its low calcium affinity? It appears it would function at 'abnormal' high calcium concentration. That's why I suggested it might be a benefit for a cell to express SERCA3 in order to overcome accidental or/and induced cytosolic calcium increases.
>Leonard

Mon Dec 14