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Cell Biology Poster Session






Abstract

Introduction

Materials & Methods

Results

Discussion & Conclusion

References




Discussion
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Downregulation Of SERCA Pump Expression In The Rat Diaphragm After Corticosteroid Treatment


Contact Person: Ghislaine Gayan-Ramirez (ghislaine.gayan-ramirez@med.kuleuven.ac.be)


Introduction

BACKGROUND

IN PATIENTS

Systemic corticosteroids in high doses are often given acutely, e.g. to treat life-threatening asthma or to prevent lung transplant rejection

Following such treatment, acute myopathy may occur and is characterized by:

- proximal and distal muscle weakness

- generalized fiber atrophy

- rhabdomyolysis and necrosis

BACKGROUND

IN RATS

5 days treatment with 80 mg/kg/day triamcinolone induced:

- diaphragm type II atrophy (CSA type IIa=-19% and IIx/b= -30%, p < 0.05)

- leftward shift of the diaphragm force-frequency curve

- prolongation of half-relaxation time (254 vs 214 msec, p < 0.05)

AIM

To examine whether sarcoplasmic/endoplasmic reticulum Ca2+-ATPase (SERCA) pumps were involved in prolonged half-relaxation time observed after corticosteroid treatment in rat diaphragm

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Gayan-Ramirez, G.; Vanzeir, L.; Decramer, M.; Wuytack, F.; (1998). Downregulation Of SERCA Pump Expression In The Rat Diaphragm After Corticosteroid Treatment. Presented at INABIS '98 - 5th Internet World Congress on Biomedical Sciences at McMaster University, Canada, Dec 7-16th. Available at URL http://www.mcmaster.ca/inabis98/cellbio/gayan-ramirez0369/index.html
© 1998 Author(s) Hold Copyright